Genesis Mission

Genesis Mission is a national initiative launched by the United States on November 24, 2025, aiming to integrate large-scale scientific datasets from federal agencies into an artificial intelligence-based research infrastructure.

Coordinated by the Department of Energy, the program seeks to accelerate scientific discovery by building a comprehensive AI platform that integrates supercomputers, national laboratories, and federal data sources. The mission is a strategic effort designed to enhance the United States’ capacity in science, technology, and national security over the long term through research on fundamental scientific models, automated experimental design, and simulation workflows.

On November 24, 2025, U.S. President Donald Trump signed an executive order launching the national initiative named “Genesis Mission,” which aims to create an artificial intelligence-based research infrastructure using federal scientific datasets.

This initiative envisions consolidating large-scale scientific databases held by federal agencies into a unified platform to train AI models, thereby accelerating scientific discovery and supporting technological innovation.

The primary goal of Genesis Mission is defined as doubling the efficiency and impact of American science and engineering within ten years and establishing an AI infrastructure capable of reducing scientific discovery timelines from years to days or even hours. To this end, the mission targets the deployment of AI systems that develop “fundamental scientific models” and automate experimental design and simulation processes on large-scale scientific datasets.

The U.S. Department of Energy (DOE) has been assigned primary responsibility for executing Genesis Mission. Darío Gil, Under Secretary for Science at DOE, has been appointed as the mission’s director, while Michael Kratsios, Director of the White House Office of Science and Technology Policy (OSTP) and the President’s advisor on science and technology, is tasked with coordinating participation from other federal agencies and ensuring alignment with national priorities.

Energy Secretary Chris Wright has stated that scientists at DOE’s 17 national laboratories, along with their supercomputing and data infrastructure, will form the core of Genesis Mission.

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At the heart of Genesis Mission is an integrated artificial intelligence platform that unifies federal scientific datasets and makes them accessible for AI-driven research. This platform, named the “American Science and Security Platform,” aims to connect supercomputers and other computational and storage resources across DOE’s national laboratories into a “closed-loop AI experimentation platform.”

The platform is designed to identify, securely collect, and process federal scientific datasets into formats suitable for training AI models. Within this framework, the platform will enable the training of fundamental scientific models, testing of new hypotheses, automation of experimental designs, acceleration of simulations, and development of prototype applications for “AI-augmented laboratories.”

According to Department of Energy statements, Genesis Mission will focus on three primary goal areas: “American energy dominance,” “advancing discovery science,” and “ensuring national security.” At least 20 scientific and technological challenges have been identified under these areas, including advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion energy, quantum information science, semiconductors, and microelectronics.

White House statements indicate that Genesis Mission will concentrate on what are described as “the greatest scientific challenges of the age,” with particular emphasis on nuclear fusion, semiconductors, critical raw materials, and space exploration.

Trump’s executive order of November 24, 2025, assigns the Department of Energy and related agencies a series of tasks to be completed within specified timeframes. Within 90 days, DOE will identify all federal information, storage, and network infrastructure capable of supporting Genesis Mission and will also determine additional resources available from industry partners.

Within 120 days, a plan must be developed to select the first datasets for inclusion in the platform and ensure their secure integration. Within 240 days, DOE is required to complete an assessment evaluating its capacity for “AI-driven experiments and production,” including automated and AI-enhanced workflows. During the same period, at least 20 scientific and technological challenges in the aforementioned areas will be identified, with the list to be reviewed and updated annually.

Although the executive order does not allocate direct funding for Genesis Mission, it tasks OSTP Director Michael Kratsios with designing grant programs or incentive schemes in collaboration with research institutions to encourage private sector participation. Kratsios is also assigned the responsibility of establishing human capital support mechanisms such as research fellowships, internship programs, and apprenticeship models in the mission’s priority areas.

White House and Department of Energy officials plan to incorporate private sector supercomputing capacity and data centers into the mission. Agreements with companies such as Nvidia and Dell are referenced in official statements, with the expectation that their AI hardware and software infrastructure will be integrated with Genesis Mission. One technology company stated that the collaboration among national laboratories, the federal government, industry, and academia will produce “one of the most complex scientific instruments ever built” to enable accelerated breakthroughs in energy, scientific discovery, and national security.

Chris Wright stated that the existing supercomputing infrastructure at DOE’s national laboratories will serve as the starting point for Genesis Mission, with future investments planned to expand this capacity. Statements emphasize that DOE operates some of the world’s most advanced supercomputing facilities and that the success of the mission depends on mobilizing all available resources.

The energy footprint of Genesis Mission is also highlighted. It is noted that the growing electricity demand from data centers used to train large-scale AI models, along with rising energy costs, has become a major policy issue. Wright asserts that AI can be used to make the electrical grid more efficient, enable greater energy supply, and reverse rising energy prices. Kratsios stated that the mission will leverage AI to accelerate experimental design and simulations, generating predictive models in areas such as protein folding and fusion plasma dynamics.

Genesis Mission is presented as part of the broader AI strategy of the Trump administration. Shortly after resuming office in January 2025, Trump requested the development of an AI Action Plan to make America the world’s AI capital and rescinded the executive order on AI safety signed by his predecessor Joe Biden.

In November 2025 statements, Trump criticized state-level AI regulations and called for a single federal standard instead of what he described as a “patchwork system” of 50 different state regimes. In this context, Genesis Mission is framed as a step toward unifying data, infrastructure, and standards at the federal level.