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Mycobacterium tuberculosis is one of the oldest and most significant pathogens in human history and the causative agent of tuberculosis. The bacterium was first identified in 1882 by German physician Robert Koch, a discovery regarded as one of the most critical breakthroughs in microbiology. Koch’s achievement was awarded the Nobel Prize in Physiology or Medicine in 1905. Today, despite advances in diagnostic and therapeutic methods, M. tuberculosis remains a major public health concern, particu